UV-Photoconversion of Ethosuximide from a Longevity-Promoting Compound to a Potent Toxin

The anticonvulsant ethosuximide has been previously shown to increase life span and promote healthspan in the nematode Caenorhabditis elegans at millimolar concentrations. Here we report that following exposure to ultraviolet irradiation at 254 nm, ethosuximide is converted into a compound that disp...

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Detalles Bibliográficos
Autores principales: Choi, Haeri, Schneider, Heather, Klum, Shannon, Chandler-Brown, Devon, Kaeberlein, Matt, Shamieh, Lara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858337/
https://www.ncbi.nlm.nih.gov/pubmed/24340038
http://dx.doi.org/10.1371/journal.pone.0082543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858337/
https://www.ncbi.nlm.nih.gov/pubmed/24340038
http://dx.doi.org/10.1371/journal.pone.0082543

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