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Mechanisms of Rapid Reactive Oxygen Species Generation in Response to Cytosolic Ca(2+) or Zn(2+) Loads in Cortical Neurons
Excessive “excitotoxic” accumulation of Ca(2+) and Zn(2+) within neurons contributes to neurodegeneration in pathological conditions including ischemia. Putative early targets of these ions, both of which are linked to increased reactive oxygen species (ROS) generation, are mitochondria and the cyto...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858366/ https://www.ncbi.nlm.nih.gov/pubmed/24340096 http://dx.doi.org/10.1371/journal.pone.0083347 |