Locus-specific editing of histone modifications at endogenous enhancers using programmable TALE-LSD1 fusions

Mammalian gene regulation is dependent on tissue-specific enhancers that can act across large distances to influence transcriptional activity(1-3). Mapping experiments have identified hundreds of thousands of putative enhancers whose functionality is supported by cell type–specific chromatin signatu...

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Detalles Bibliográficos
Autores principales: Mendenhall, Eric M., Williamson, Kaylyn E., Reyon, Deepak, Zou, James Y., Ram, Oren, Joung, J. Keith, Bernstein, Bradley E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858395/
https://www.ncbi.nlm.nih.gov/pubmed/24013198
http://dx.doi.org/10.1038/nbt.2701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858395/
https://www.ncbi.nlm.nih.gov/pubmed/24013198
http://dx.doi.org/10.1038/nbt.2701

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