Cargando…

Retrograde Endocannabinoid Signaling Reduces GABAergic Synaptic Transmission to Gonadotropin-Releasing Hormone Neurons

Cannabinoids suppress fertility via reducing hypothalamic GnRH output. γ-Aminobutyric acid (GABA)(A) receptor (GABA(A)-R)-mediated transmission is a major input to GnRH cells that can be excitatory. We hypothesized that cannabinoids act via inhibiting GABAergic input. We performed loose-patch electr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Farkas, Imre, Kalló, Imre, Deli, Levente, Vida, Barbara, Hrabovszky, Erik, Fekete, Csaba, Moenter, Suzanne M., Watanabe, Masahiko, Liposits, Zsolt
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Endocrine Society 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858799/ https://www.ncbi.nlm.nih.gov/pubmed/20926585 http://dx.doi.org/10.1210/en.2010-0638

Ejemplares similares

Glucagon-Like Peptide-1 Excites Firing and Increases GABAergic Miniature Postsynaptic Currents (mPSCs) in Gonadotropin-Releasing Hormone (GnRH) Neurons of the Male Mice via Activation of Nitric Oxide (NO) and Suppression of Endocannabinoid Signaling Pathways
por: Farkas, Imre, et al.
Publicado: (2016)

Area-specific analysis of the distribution of hypothalamic neurons projecting to the rat ventral tegmental area, with special reference to the GABAergic and glutamatergic efferents
por: Kalló, Imre, et al.
Publicado: (2015)

Secretin Regulates Excitatory GABAergic Neurotransmission to GnRH Neurons via Retrograde NO Signaling Pathway in Mice
por: Csillag, Veronika, et al.
Publicado: (2019)

Ghrelin Decreases Firing Activity of Gonadotropin-Releasing Hormone (GnRH) Neurons in an Estrous Cycle and Endocannabinoid Signaling Dependent Manner
por: Farkas, Imre, et al.
Publicado: (2013)

Estradiol Increases Glutamate and GABA Neurotransmission into GnRH Neurons via Retrograde NO-Signaling in Proestrous Mice during the Positive Estradiol Feedback Period
por: Farkas, Imre, et al.
Publicado: (2018)

Ovariectomy and Subsequent Treatment with Estrogen Receptor Agonists Tune the Innate Immune System of the Hippocampus in Middle-Aged Female Rats
por: Sárvári, Miklós, et al.
Publicado: (2014)

Endocannabinoid and nitric oxide systems of the hypothalamic paraventricular nucleus mediate effects of NPY on energy expenditure
por: Péterfi, Zoltán, et al.
Publicado: (2018)

Long-Term Estrogen Receptor Beta Agonist Treatment Modifies the Hippocampal Transcriptome in Middle-Aged Ovariectomized Rats
por: Sárvári, Miklós, et al.
Publicado: (2016)

Gonadal Cycle-Dependent Expression of Genes Encoding Peptide-, Growth Factor-, and Orphan G-Protein-Coupled Receptors in Gonadotropin- Releasing Hormone Neurons of Mice
por: Vastagh, Csaba, et al.
Publicado: (2021)

Afferent Neuronal Control of Type-I Gonadotropin Releasing Hormone Neurons in the Human
por: Hrabovszky, Erik, et al.
Publicado: (2013)

Estrogen Receptor Beta and 2-arachidonoylglycerol Mediate the Suppressive Effects of Estradiol on Frequency of Postsynaptic Currents in Gonadotropin-Releasing Hormone Neurons of Metestrous Mice: An Acute Slice Electrophysiological Study
por: Bálint, Flóra, et al.
Publicado: (2016)

Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes
por: Sárvári, Miklós, et al.
Publicado: (2012)

Proestrus Differentially Regulates Expression of Ion Channel and Calcium Homeostasis Genes in GnRH Neurons of Mice
por: Vastagh, Csaba, et al.
Publicado: (2019)

Estrogens regulate neuroinflammatory genes via estrogen receptors α and β in the frontal cortex of middle-aged female rats
por: Sárvári, Miklós, et al.
Publicado: (2011)

Networking of glucagon-like peptide-1 axons with GnRH neurons in the basal forebrain of male mice revealed by 3DISCO-based immunocytochemistry and optogenetics
por: Vastagh, Csaba, et al.
Publicado: (2020)

GnRH Neurons Provide Direct Input to Hypothalamic Tyrosine Hydroxylase Immunoreactive Neurons Which Is Maintained During Lactation
por: Bardóczi, Zsuzsanna, et al.
Publicado: (2018)

The Amygdala as a Neurobiological Target for Ghrelin in Rats: Neuroanatomical, Electrophysiological and Behavioral Evidence
por: Alvarez-Crespo, Mayte, et al.
Publicado: (2012)

Changes in GABAergic Transmission to and Intrinsic Excitability of Gonadotropin-Releasing Hormone (GnRH) Neurons during the Estrous Cycle in Mice
por: Adams, Caroline, et al.
Publicado: (2018)

Sexual Dimorphism of Kisspeptin and Neurokinin B Immunoreactive Neurons in the Infundibular Nucleus of Aged Men and Women
por: Hrabovszky, Erik, et al.
Publicado: (2011)

A Novel Pathway Regulates Thyroid Hormone Availability in Rat and Human Hypothalamic Neurosecretory Neurons
por: Kalló, Imre, et al.
Publicado: (2012)

Control of synaptic function by endocannabinoid-mediated retrograde signaling
por: KANO, Masanobu
Publicado: (2014)

Characterization of orexin input to dopamine neurons of the ventral tegmental area projecting to the medial prefrontal cortex and shell of nucleus accumbens
por: Kalló, Imre, et al.
Publicado: (2022)

Lateral hypothalamic orexin and melanin-concentrating hormone neurons provide direct input to gonadotropin-releasing hormone neurons in the human
por: Skrapits, Katalin, et al.
Publicado: (2015)

The Orexigenic Effect of Ghrelin Is Mediated through Central Activation of the Endogenous Cannabinoid System
por: Kola, Blerina, et al.
Publicado: (2008)

The cryptic gonadotropin-releasing hormone neuronal system of human basal ganglia
por: Skrapits, Katalin, et al.
Publicado: (2021)

BDNF Expression in Cortical GABAergic Interneurons
por: Tomás, Federico José Barreda, et al.
Publicado: (2020)

Coordinated regulation of endocannabinoid-mediated retrograde synaptic suppression in the cerebellum by neuronal and astrocytic monoacylglycerol lipase
por: Liu, Xiaojie, et al.
Publicado: (2016)

Distinct Localization of SNAP47 Protein in GABAergic and Glutamatergic Neurons in the Mouse and the Rat Hippocampus
por: Münster-Wandowski, Agnieszka, et al.
Publicado: (2017)

The role of gonadotropin‐releasing hormone neurons in polycystic ovary syndrome
por: McCartney, Christopher R., et al.
Publicado: (2022)

Endocannabinoid signaling in synaptic function
por: Noriega‐Prieto, Jose Antonio, et al.
Publicado: (2022)

Endocannabinoid Signaling for GABAergic-Microglia (Mis)Communication in the Brain Aging
por: Carrera, Jorge, et al.
Publicado: (2021)

Firing patterns of gonadotropin-releasing hormone neurons are sculpted by their biologic state
por: Penix, Jonathon, et al.
Publicado: (2020)

Expression of type one cannabinoid receptor in different subpopulation of kisspeptin neurons and kisspeptin afferents to GnRH neurons in female mice
por: Wilheim, Tamás, et al.
Publicado: (2021)

Gonadotropin-Releasing Hormone (GnRH) Neuron Potassium Currents and Excitability in Both Sexes Exhibit Minimal Changes upon Removal of Negative Feedback
por: DeFazio, R. Anthony, et al.
Publicado: (2021)

Lights on Endocannabinoid-Mediated Synaptic Potentiation
por: Piette, Charlotte, et al.
Publicado: (2020)

The Higher Sensitivity of GABAergic Compared to Glutamatergic Neurons to Growth-Promoting C3bot Treatment Is Mediated by Vimentin
por: Adolf, Andrej, et al.
Publicado: (2020)

Orexinergic Input to Dopaminergic Neurons of the Human Ventral Tegmental Area
por: Hrabovszky, Erik, et al.
Publicado: (2013)

Neuropeptide co-expression in hypothalamic kisspeptin neurons of laboratory animals and the human
por: Skrapits, Katalin, et al.
Publicado: (2015)

Impact of Proestrus on Gene Expression in the Medial Preoptic Area of Mice
por: Vastagh, Csaba, et al.
Publicado: (2017)

NMDA Receptors in GABAergic Synapses during Postnatal Development
por: Cserép, Csaba, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_n69ripn2o52deav4mp53hu7u75