Dipeptidyl Peptidase IV Inhibition Activates CREB and Improves Islet Vascularization through VEGF-A/VEGFR-2 Signaling Pathway

Substitution of pancreatic islets is a potential therapy to treat diabetes and it depends on reconstitution of islet’s capillary network. In this study, we addressed the question whether stabilization of Glucagon-Like-Peptide-1 (GLP-1) by inhibiting Dipeptidyl Peptidase-IV (DPP-IV) increases β-cell...

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Detalles Bibliográficos
Autores principales: Samikannu, Balaji, Chen, Chunguang, Lingwal, Neelam, Padmasekar, Manju, Engel, Felix B., Linn, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859629/
https://www.ncbi.nlm.nih.gov/pubmed/24349326
http://dx.doi.org/10.1371/journal.pone.0082639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859629/
https://www.ncbi.nlm.nih.gov/pubmed/24349326
http://dx.doi.org/10.1371/journal.pone.0082639

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