Inhibition of PI3K/mTOR Overcomes Nilotinib Resistance in BCR-ABL1 Positive Leukemia Cells through Translational Down-Regulation of MDM2

Chronic myeloid leukemia (CML) is a cytogenetic disorder resulting from formation of the Philadelphia chromosome (Ph), that is, the t(9;22) chromosomal translocation and the formation of the BCR-ABL1 fusion protein. Tyrosine kinase inhibitors (TKI), such as imatinib and nilotinib, have emerged as le...

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Detalles Bibliográficos
Autores principales: Ding, Jie, Romani, Julia, Zaborski, Margarete, MacLeod, Roderick A. F., Nagel, Stefan, Drexler, Hans G., Quentmeier, Hilmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859659/
https://www.ncbi.nlm.nih.gov/pubmed/24349524
http://dx.doi.org/10.1371/journal.pone.0083510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859659/
https://www.ncbi.nlm.nih.gov/pubmed/24349524
http://dx.doi.org/10.1371/journal.pone.0083510

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