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mRNA: From a chemical blueprint for protein production to an off-the-shelf therapeutic

Two decades ago, mRNA became the focus of research in molecular medicine and was proposed as an active pharmaceutical ingredient for the therapy of cancer. In this regard, mRNA has been mainly used for ex vivo modification of antigen-presenting cells (APCs), such as dendritic cells (DCs). This vacci...

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Detalles Bibliográficos
Autores principales: Van Lint, Sandra, Heirman, Carlo, Thielemans, Kris, Breckpot, Karine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859745/
https://www.ncbi.nlm.nih.gov/pubmed/23291946
http://dx.doi.org/10.4161/hv.22661