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Exploring Early Stages of the Chemical Unfolding of Proteins at the Proteome Scale

After decades of using urea as denaturant, the kinetic role of this molecule in the unfolding process is still undefined: does urea actively induce protein unfolding or passively stabilize the unfolded state? By analyzing a set of 30 proteins (representative of all native folds) through extensive mo...

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Detalles Bibliográficos
Autores principales: Candotti, Michela, Pérez, Alberto, Ferrer-Costa, Carles, Rueda, Manuel, Meyer, Tim, Gelpí, Josep Lluís, Orozco, Modesto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861036/
https://www.ncbi.nlm.nih.gov/pubmed/24348236
http://dx.doi.org/10.1371/journal.pcbi.1003393