Decipher the Mechanisms of Protein Conformational Changes Induced by Nucleotide Binding through Free-Energy Landscape Analysis: ATP Binding to Hsp70

ATP regulates the function of many proteins in the cell by transducing its binding and hydrolysis energies into protein conformational changes by mechanisms which are challenging to identify at the atomic scale. Based on molecular dynamics (MD) simulations, a method is proposed to analyze the struct...

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Detalles Bibliográficos
Autores principales: Nicolaï, Adrien, Delarue, Patrice, Senet, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861046/
https://www.ncbi.nlm.nih.gov/pubmed/24348227
http://dx.doi.org/10.1371/journal.pcbi.1003379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861046/
https://www.ncbi.nlm.nih.gov/pubmed/24348227
http://dx.doi.org/10.1371/journal.pcbi.1003379

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