Hypoxic Tumor Environments Exhibit Disrupted Collagen I Fibers and Low Macromolecular Transport

Hypoxic tumor microenvironments result in an aggressive phenotype and resistance to therapy that lead to tumor progression, recurrence, and metastasis. While poor vascularization and the resultant inadequate drug delivery are known to contribute to drug resistance, the effect of hypoxia on molecular...

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Detalles Bibliográficos
Autores principales: Kakkad, Samata M., Penet, Marie-France, Akhbardeh, Alireza, Pathak, Arvind P., Solaiyappan, Meiyappan, Raman, Venu, Leibfritz, Dieter, Glunde, Kristine, Bhujwalla, Zaver M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861360/
https://www.ncbi.nlm.nih.gov/pubmed/24349142
http://dx.doi.org/10.1371/journal.pone.0081869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861360/
https://www.ncbi.nlm.nih.gov/pubmed/24349142
http://dx.doi.org/10.1371/journal.pone.0081869

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