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Hypoxic Tumor Environments Exhibit Disrupted Collagen I Fibers and Low Macromolecular Transport
Hypoxic tumor microenvironments result in an aggressive phenotype and resistance to therapy that lead to tumor progression, recurrence, and metastasis. While poor vascularization and the resultant inadequate drug delivery are known to contribute to drug resistance, the effect of hypoxia on molecular...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861360/ https://www.ncbi.nlm.nih.gov/pubmed/24349142 http://dx.doi.org/10.1371/journal.pone.0081869 |