A Vaccine That Co-Targets Tumor Cells and Cancer Associated Fibroblasts Results in Enhanced Antitumor Activity by Inducing Antigen Spreading

Dendritic cell (DC) vaccines targeting only cancer cells have produced limited antitumor activity in most clinical studies. Targeting cancer-associated fibroblasts (CAFs) in addition to cancer cells may enhance antitumor effects, since CAFs, the central component of the tumor stroma, directly suppor...

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Detalles Bibliográficos
Autores principales: Gottschalk, Stephen, Yu, Feng, Ji, Minjun, Kakarla, Sunitha, Song, Xiao-Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861387/
https://www.ncbi.nlm.nih.gov/pubmed/24349329
http://dx.doi.org/10.1371/journal.pone.0082658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861387/
https://www.ncbi.nlm.nih.gov/pubmed/24349329
http://dx.doi.org/10.1371/journal.pone.0082658

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