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Changes in Mitochondrial Carriers Exhibit Stress-Specific Signatures in INS-1Eβ-Cells Exposed to Glucose Versus Fatty Acids
Chronic exposure of β-cells to metabolic stresses impairs their function and potentially induces apoptosis. Mitochondria play a central role in coupling glucose metabolism to insulin secretion. However, little is known on mitochondrial responses to specific stresses; i.e. low versus high glucose, sa...
Autores principales: | Brun, Thierry, Scarcia, Pasquale, Li, Ning, Gaudet, Pascale, Duhamel, Dominique, Palmieri, Ferdinando, Maechler, Pierre |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861392/ https://www.ncbi.nlm.nih.gov/pubmed/24349266 http://dx.doi.org/10.1371/journal.pone.0082364 |
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