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Time Scales in Epigenetic Dynamics and Phenotypic Heterogeneity of Embryonic Stem Cells

A remarkable feature of the self-renewing population of embryonic stem cells (ESCs) is their phenotypic heterogeneity: Nanog and other marker proteins of ESCs show large cell-to-cell variation in their expression level, which should significantly influence the differentiation process of individual c...

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Detalles Bibliográficos
Autores principales: Sasai, Masaki, Kawabata, Yudai, Makishi, Koh, Itoh, Kazuhito, Terada, Tomoki P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861442/
https://www.ncbi.nlm.nih.gov/pubmed/24348228
http://dx.doi.org/10.1371/journal.pcbi.1003380