Structures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling

Zinc RING finger 3 (ZNRF3) and its homolog RING finger 43 (RNF43) antagonize Wnt signaling in adult stem cells by ubiquitinating Frizzled receptors (FZD), which leads to endocytosis of the Wnt receptor. Conversely, binding of ZNRF3/RNF43 to LGR4-6 – R-spondin blocks Frizzled ubiquitination and enhan...

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Detalles Bibliográficos
Autores principales: Peng, Weng Chuan, de Lau, Wim, Madoori, Pramod K., Forneris, Federico, Granneman, Joke C. M., Clevers, Hans, Gros, Piet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861454/
https://www.ncbi.nlm.nih.gov/pubmed/24349440
http://dx.doi.org/10.1371/journal.pone.0083110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861454/
https://www.ncbi.nlm.nih.gov/pubmed/24349440
http://dx.doi.org/10.1371/journal.pone.0083110

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