Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor

Elevated glucagon levels and increased hepatic glucagon receptor (GCGR) signaling contribute to hyperglycemia in type 2 diabetes. We have identified a monoclonal antibody that inhibits GCGR, a class B G-protein coupled receptor (GPCR), through a unique allosteric mechanism. Receptor inhibition is me...

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Detalles Bibliográficos
Autores principales: Mukund, Susmith, Shang, Yonglei, Clarke, Holly J., Madjidi, Azadeh, Corn, Jacob E., Kates, Lance, Kolumam, Ganesh, Chiang, Vicky, Luis, Elizabeth, Murray, Jeremy, Zhang, Yingnan, Hötzel, Isidro, Koth, Christopher M., Allan, Bernard B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861664/
https://www.ncbi.nlm.nih.gov/pubmed/24189067
http://dx.doi.org/10.1074/jbc.M113.496984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861664/
https://www.ncbi.nlm.nih.gov/pubmed/24189067
http://dx.doi.org/10.1074/jbc.M113.496984

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