Fbw7 dimerization determines the specificity and robustness of substrate degradation

The Fbw7 tumor suppressor targets a broad network of proteins for ubiquitylation. Here we show critical functions for Fbw7 dimerization in regulating the specificity and robustness of degradation. Dimerization enables Fbw7 to target substrates through concerted binding to two suboptimal and independ...

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Detalles Bibliográficos
Autores principales: Welcker, Markus, Larimore, Elizabeth A., Swanger, Jherek, Bengoechea-Alonso, Maria T., Grim, Jonathan E., Ericsson, Johan, Zheng, Ning, Clurman, Bruce E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861666/
https://www.ncbi.nlm.nih.gov/pubmed/24298052
http://dx.doi.org/10.1101/gad.229195.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861666/
https://www.ncbi.nlm.nih.gov/pubmed/24298052
http://dx.doi.org/10.1101/gad.229195.113

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