The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis

Insulin-like growth factor 2 (IGF2), a developmentally regulated and maternally imprinted gene, is frequently overexpressed in pediatric cancers. Although loss of imprinting (LOI) at fetal promoters contributes to increased IGF2 in tumors, the magnitude of IGF2 expression suggests the involvement of...

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Detalles Bibliográficos
Autores principales: Liu, Mingzhu, Roth, Anna, Yu, Min, Morris, Robert, Bersani, Francesca, Rivera, Miguel N., Lu, Jun, Shioda, Toshihiro, Vasudevan, Shobha, Ramaswamy, Sridhar, Maheswaran, Shyamala, Diederichs, Sven, Haber, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861668/
https://www.ncbi.nlm.nih.gov/pubmed/24298054
http://dx.doi.org/10.1101/gad.224170.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861668/
https://www.ncbi.nlm.nih.gov/pubmed/24298054
http://dx.doi.org/10.1101/gad.224170.113

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