An RNAi-Based Dimorphic Genetic Screen Identified the Double Bromodomain Protein BET-1 as a Sumo-Dependent Attenuator of RAS-Mediated Signalling

Attenuation of RAS/RAF/MAPK signalling is essential to prevent hyperactivation of this oncogenic pathway. In C. elegans, the sumoylation pathway and a combination of histone tail modifications regulate gene expression to attenuate the LET-60 (RAS) signalling pathway. We hypothesised that a number of...

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Detalles Bibliográficos
Autores principales: Gee, Fiona, Fisher, Kate, Klemstein, Ulrike, Poulin, Gino B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862036/
https://www.ncbi.nlm.nih.gov/pubmed/24349540
http://dx.doi.org/10.1371/journal.pone.0083659

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862036/
https://www.ncbi.nlm.nih.gov/pubmed/24349540
http://dx.doi.org/10.1371/journal.pone.0083659

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