Exploring the mode of action of ebselen in Trypanosoma brucei hexokinase inhibition()

Glycolysis is essential to Trypanosoma brucei, the causative agent of African sleeping sickness, suggesting enzymes in the pathway could be targets for drug development. Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one, EbSe) was identified in a screen as a potent inhibitor of T. brucei hexokinase 1...

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Detalles Bibliográficos
Autores principales: Joice, April C., Harris, Michael T., Kahney, Elizabeth W., Dodson, Heidi C., Maselli, Andrew G., Whitehead, Daniel C., Morris, James C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862409/
https://www.ncbi.nlm.nih.gov/pubmed/24533305
http://dx.doi.org/10.1016/j.ijpddr.2013.08.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862409/
https://www.ncbi.nlm.nih.gov/pubmed/24533305
http://dx.doi.org/10.1016/j.ijpddr.2013.08.002

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