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Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake()

It has long been established that the Trypanosoma brucei TbAT1/P2 aminopurine transporter is involved in the uptake of diamidine and arsenical drugs including pentamidine, diminazene aceturate and melarsoprol. Accordingly, it was proposed that the closest Trypanosoma congolense paralogue, TcoAT1, mi...

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Detalles Bibliográficos
Autores principales: Munday, Jane C., Rojas López, Karla E., Eze, Anthonius A., Delespaux, Vincent, Van Den Abbeele, Jan, Rowan, Tim, Barrett, Michael P., Morrison, Liam J., de Koning, Harry P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862423/
https://www.ncbi.nlm.nih.gov/pubmed/24533295
http://dx.doi.org/10.1016/j.ijpddr.2013.01.004