Cargando…

Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake()

It has long been established that the Trypanosoma brucei TbAT1/P2 aminopurine transporter is involved in the uptake of diamidine and arsenical drugs including pentamidine, diminazene aceturate and melarsoprol. Accordingly, it was proposed that the closest Trypanosoma congolense paralogue, TcoAT1, mi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Munday, Jane C., Rojas López, Karla E., Eze, Anthonius A., Delespaux, Vincent, Van Den Abbeele, Jan, Rowan, Tim, Barrett, Michael P., Morrison, Liam J., de Koning, Harry P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862423/ https://www.ncbi.nlm.nih.gov/pubmed/24533295 http://dx.doi.org/10.1016/j.ijpddr.2013.01.004

Ejemplares similares

Drug quality analysis of isometamidium chloride hydrochloride and diminazene diaceturate used for the treatment of African animal trypanosomosis in West Africa
por: Bengaly, Zakaria, et al.
Publicado: (2018)

Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy
por: Alzahrani, Khalid J.H., et al.
Publicado: (2017)

Highly Efficient Uptake of TcO(4)(–) by Imidazolium-Functionalized Wood Sawdust
por: Dong, Fangfei, et al.
Publicado: (2021)

Mechanisms of AMPA Receptor Inhibition by Diminazene
por: Zhigulin, A. S., et al.
Publicado: (2022)

Improved PCR-RFLP for the Detection of Diminazene Resistance in Trypanosoma congolense under Field Conditions Using Filter Papers for Sample Storage
por: Vitouley, Hervé Sèna, et al.
Publicado: (2011)

Molecular basis of inhibition of acid sensing ion channel 1A by diminazene
por: Krauson, Aram J., et al.
Publicado: (2018)

Functional analysis of drug resistance‐associated mutations in the T rypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein
por: Munday, Jane C., et al.
Publicado: (2015)

Oxygen-dependent, alternative promoter controls translation of tco1(+) in fission yeast
por: Sehgal, Alfica, et al.
Publicado: (2008)

Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F(1)F(o)-ATPase
por: Eze, Anthonius A., et al.
Publicado: (2016)

Development of unstable resistance to diminazene aceturate in Babesia bovis
por: Tuvshintulga, Bumduuren, et al.
Publicado: (2019)

Biodynamic parameters of micellar diminazene in sheep erythrocytes and blood plasma
por: Staroverov, Sergey A., et al.
Publicado: (2011)

Diminazene aceturate attenuates hepatic ischemia/reperfusion injury in mice
por: Yoon, So Hye, et al.
Publicado: (2022)

trans-K(3)[TcO(2)(CN)(4)]
por: Chatterjee, Sayandev, et al.
Publicado: (2010)

Plasmonic and Conductive Structures of TCO Films with Embedded Cu Nanoparticles
por: Boscarino, Stefano, et al.
Publicado: (2022)

Regulation of Vid-dependent degradation of FBPase by TCO89, a component of TOR Complex 1
por: Yan, Yan, et al.
Publicado: (2010)

Use of recombinant S1 spike polypeptide to develop a TCoV-specific antibody ELISA
por: Gomaa, Maged H., et al.
Publicado: (2009)

Covalent Immobilization of Antibodies through Tetrazine-TCO Reaction to Improve Sensitivity of ELISA Technique
por: García-Maceira, Tania, et al.
Publicado: (2021)

Topical administration of diminazene aceturate decreases inflammation in endotoxin-induced uveitis
por: Zheng, Changwei, et al.
Publicado: (2015)

Nephroprotective effects of diminazene on doxorubicin-induced acute kidney injury in rats
por: Suleimani, Yousuf Al, et al.
Publicado: (2023)

(99)TcO(4)(−) remediation by a cationic polymeric network
por: Li, Jie, et al.
Publicado: (2018)

The animal trypanosomiases and their chemotherapy: a review
por: GIORDANI, FEDERICA, et al.
Publicado: (2016)

Diminazene Aceturate Improves Cardiac Fibrosis and Diastolic Dysfunction in Rats with Kidney Disease
por: Velkoska, Elena, et al.
Publicado: (2016)

β-Cyclodextrin as a Functional Excipient Used for Enhancing the Diminazene Aceturate Bioavailability
por: Marangoci, Narcisa, et al.
Publicado: (2019)

Trypanosomiasis challenge estimation using the diminazene aceturate (Berenil) index in Zebu in Gabon
por: Cossic, Brieuc G. A., et al.
Publicado: (2017)

Anion-adaptive crystalline cationic material for (99)TcO(4)(−) trapping
por: Mei, Lei, et al.
Publicado: (2019)

Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter
por: Quashie, Neils B, et al.
Publicado: (2010)

Diminazene Aceturate (Berenil) Modulates the Host Cellular and Inflammatory Responses to Trypanosoma congolense Infection
por: Kuriakose, Shiby, et al.
Publicado: (2012)

The Preventive Effects of Diminazene Aceturate in Renal Ischemia/Reperfusion Injury in Male and Female Rats
por: Malek, Maryam, et al.
Publicado: (2014)

The small molecule drug diminazene aceturate inhibits liver injury and biliary fibrosis in mice
por: Rajapaksha, Indu G., et al.
Publicado: (2018)

Diminazene aceturate exacerbates renal fibrosis after unilateral ureteral obstruction in female mice
por: Kim, Yosep, et al.
Publicado: (2023)

Nucleoside Transport and Nucleobase Uptake Null Mutants in Leishmania mexicana for the Routine Expression and Characterization of Purine and Pyrimidine Transporters
por: Aldfer, Mustafa M., et al.
Publicado: (2022)

Simultaneous Determination and Stability Studies on Diminazene Diaceturate and Phenazone Using Developed Derivative Spectrophotometric Method
por: Akode, Ruaa Mohamed, et al.
Publicado: (2017)

Comparative experimental studies on Trypanosoma isolates in mice and response to diminazene aceturate and isometamidium chloride treatment
por: Yayeh, Muluken, et al.
Publicado: (2018)

Establishing Babesia bovis-Free Tick Colony Following Treatment of the Host with Diminazene Aceturate (Berenil)
por: Tirosh-Levy, Sharon, et al.
Publicado: (2021)

Diminazene aceturate mitigates cardiomyopathy by interfering with renin-angiotensin system in a septic rat model
por: Lu, Zhaoqing, et al.
Publicado: (2022)

TCO, a Putative Transcriptional Regulator in Arabidopsis, Is a Target of the Protein Kinase CK2
por: Weinman, Laina M., et al.
Publicado: (2018)

Hyperthyroidism secondary to disseminated differentiated thyroid cancer on (99m)TcO(4) scan
por: Hu, Yan, et al.
Publicado: (2019)

TcoFBase: a comprehensive database for decoding the regulatory transcription co-factors in human and mouse
por: Zhang, Yuexin, et al.
Publicado: (2021)

The individual components of commercial isometamidium do not possess stronger trypanocidal activity than the mixture, nor bypass isometamidium resistance
por: Eze, Anthonius A., et al.
Publicado: (2019)

In vitro activity and in vivo efficacy of a combination therapy of diminazene and chloroquine against murine visceral leishmaniasis
por: Mwololo, Samuel W, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_rqkejhvs02q58ouek39pag905r