A common signaling pathway is activated in erythroid cells expressing high levels of fetal hemoglobin: a potential role for cAMP-elevating agents in β-globin disorders

BACKGROUND: Although erythroid cells prepared from fetal liver, cord blood, or blood from β-thalassemia patients are known to express fetal hemoglobin at high levels, the underlying mechanisms remain elusive. We previously showed that cyclic nucleotides such as cAMP and cGMP induce fetal hemoglobin...

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Detalles Bibliográficos
Autores principales: Ikuta, Tohru, Kuroyanagi, Yuichi, Odo, Nadine, Liu, Siyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862583/
https://www.ncbi.nlm.nih.gov/pubmed/24353450
http://dx.doi.org/10.2147/JBM.S54671

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862583/
https://www.ncbi.nlm.nih.gov/pubmed/24353450
http://dx.doi.org/10.2147/JBM.S54671

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