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Hemodialysis does not alter in vitro hepatic CYP3A4 and CYP2D6 metabolic activity in uremic serum
There is a paucity of studies evaluating the change in liver metabolism in subjects receiving hemodialysis. The purpose of this study was to compare the effect of uremic toxins on hepatic cytochrome P450 (CYP)3A4 and CYP2D6 metabolism before and after a 4-hour hemodialysis session. Midazolam and dex...
Autores principales: | Decker, Brian S, O’Neill, Kalisha D, Chambers, Mary A, Slaven, James E, Yu, Zhangsheng, Jones, David R, Moe, Sharon M |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862653/ https://www.ncbi.nlm.nih.gov/pubmed/24353447 http://dx.doi.org/10.2147/CPAA.S54381 |
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