PTEN Increases Autophagy and Inhibits the Ubiquitin-Proteasome Pathway in Glioma Cells Independently of its Lipid Phosphatase Activity

Two major mechanisms of intracellular protein degradation, autophagy and the ubiquitin-proteasome pathway, operate in mammalian cells. PTEN, which is frequently mutated in glioblastomas, is a tumor suppressor gene that encodes a dual specificity phosphatase that antagonizes the phosphatidylinositol...

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Detalles Bibliográficos
Autores principales: Errafiy, Rajaa, Aguado, Carmen, Ghislat, Ghita, Esteve, Juan M., Gil, Anabel, Loutfi, Mohammed, Knecht, Erwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862694/
https://www.ncbi.nlm.nih.gov/pubmed/24349488
http://dx.doi.org/10.1371/journal.pone.0083318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862694/
https://www.ncbi.nlm.nih.gov/pubmed/24349488
http://dx.doi.org/10.1371/journal.pone.0083318

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