Synthesis of Two Novel 3-Amino-5-[4-chloro-2-phenoxyphenyl]-4H-1,2,4-triazoles with Anticonvulsant Activity

Two novel 3-amino-5-(4-choloro-2-phenoxyphenyl)-4H-1,2,4-triazole derivatives were prepared and their anticonvulsant activity was measured by evaluation of the ability of these compounds to protect mice against convulsion induced by lethal doses of pentylenetetrazole (PTZ). Diazepam (Sigma) was cons...

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Autores principales: Mahdavi, Mohammad, Akbarzadeh, Tahmineh, Sheibani, Vahid, Abbasi, Maryam, Firoozpour, Loghman, Tabatabai, Sayyed Abbas, Shafiee, Abbas, Foroumadi, Alireza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863441/
https://www.ncbi.nlm.nih.gov/pubmed/24363736
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author Mahdavi, Mohammad
Akbarzadeh, Tahmineh
Sheibani, Vahid
Abbasi, Maryam
Firoozpour, Loghman
Tabatabai, Sayyed Abbas
Shafiee, Abbas
Foroumadi, Alireza
author_facet Mahdavi, Mohammad
Akbarzadeh, Tahmineh
Sheibani, Vahid
Abbasi, Maryam
Firoozpour, Loghman
Tabatabai, Sayyed Abbas
Shafiee, Abbas
Foroumadi, Alireza
author_sort Mahdavi, Mohammad
collection PubMed
description Two novel 3-amino-5-(4-choloro-2-phenoxyphenyl)-4H-1,2,4-triazole derivatives were prepared and their anticonvulsant activity was measured by evaluation of the ability of these compounds to protect mice against convulsion induced by lethal doses of pentylenetetrazole (PTZ). Diazepam (Sigma) was considered as a positive control drug with anticonvulsant effect [ED(50) = 1.2 (0.5-1.9) mg/Kg]. Amongst the compounds tested, compound 3, 3-amino-5- [4-chloro-2-(2-flurophenoxy)phenyl]-4H-1,2,4-triazole, showed potent anticonvulsant activity [ED(50) = 1.4 (1.0-2.2) mg/Kg] compared to diazepam.
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spelling pubmed-38634412013-12-20 Synthesis of Two Novel 3-Amino-5-[4-chloro-2-phenoxyphenyl]-4H-1,2,4-triazoles with Anticonvulsant Activity Mahdavi, Mohammad Akbarzadeh, Tahmineh Sheibani, Vahid Abbasi, Maryam Firoozpour, Loghman Tabatabai, Sayyed Abbas Shafiee, Abbas Foroumadi, Alireza Iran J Pharm Res Original Article Two novel 3-amino-5-(4-choloro-2-phenoxyphenyl)-4H-1,2,4-triazole derivatives were prepared and their anticonvulsant activity was measured by evaluation of the ability of these compounds to protect mice against convulsion induced by lethal doses of pentylenetetrazole (PTZ). Diazepam (Sigma) was considered as a positive control drug with anticonvulsant effect [ED(50) = 1.2 (0.5-1.9) mg/Kg]. Amongst the compounds tested, compound 3, 3-amino-5- [4-chloro-2-(2-flurophenoxy)phenyl]-4H-1,2,4-triazole, showed potent anticonvulsant activity [ED(50) = 1.4 (1.0-2.2) mg/Kg] compared to diazepam. Shaheed Beheshti University of Medical Sciences 2010 /pmc/articles/PMC3863441/ /pubmed/24363736 Text en © 2010 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Mahdavi, Mohammad
Akbarzadeh, Tahmineh
Sheibani, Vahid
Abbasi, Maryam
Firoozpour, Loghman
Tabatabai, Sayyed Abbas
Shafiee, Abbas
Foroumadi, Alireza
Synthesis of Two Novel 3-Amino-5-[4-chloro-2-phenoxyphenyl]-4H-1,2,4-triazoles with Anticonvulsant Activity
title Synthesis of Two Novel 3-Amino-5-[4-chloro-2-phenoxyphenyl]-4H-1,2,4-triazoles with Anticonvulsant Activity
title_full Synthesis of Two Novel 3-Amino-5-[4-chloro-2-phenoxyphenyl]-4H-1,2,4-triazoles with Anticonvulsant Activity
title_fullStr Synthesis of Two Novel 3-Amino-5-[4-chloro-2-phenoxyphenyl]-4H-1,2,4-triazoles with Anticonvulsant Activity
title_full_unstemmed Synthesis of Two Novel 3-Amino-5-[4-chloro-2-phenoxyphenyl]-4H-1,2,4-triazoles with Anticonvulsant Activity
title_short Synthesis of Two Novel 3-Amino-5-[4-chloro-2-phenoxyphenyl]-4H-1,2,4-triazoles with Anticonvulsant Activity
title_sort synthesis of two novel 3-amino-5-[4-chloro-2-phenoxyphenyl]-4h-1,2,4-triazoles with anticonvulsant activity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863441/
https://www.ncbi.nlm.nih.gov/pubmed/24363736
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