Cargando…

Synthesis of Two Novel 3-Amino-5-[4-chloro-2-phenoxyphenyl]-4H-1,2,4-triazoles with Anticonvulsant Activity

Two novel 3-amino-5-(4-choloro-2-phenoxyphenyl)-4H-1,2,4-triazole derivatives were prepared and their anticonvulsant activity was measured by evaluation of the ability of these compounds to protect mice against convulsion induced by lethal doses of pentylenetetrazole (PTZ). Diazepam (Sigma) was cons...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mahdavi, Mohammad, Akbarzadeh, Tahmineh, Sheibani, Vahid, Abbasi, Maryam, Firoozpour, Loghman, Tabatabai, Sayyed Abbas, Shafiee, Abbas, Foroumadi, Alireza
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Shaheed Beheshti University of Medical Sciences 2010
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863441/ https://www.ncbi.nlm.nih.gov/pubmed/24363736

Ejemplares similares

Novel 1,2,4-oxadiazole derivatives as selective butyrylcholinesterase inhibitors: Design, synthesis and biological evaluation
por: Nazari, Maryam, et al.
Publicado: (2021)

Design, synthesis and biological assessment of new 1-benzyl-4-((4-oxoquinazolin-3(4H)-yl)methyl) pyridin-1-ium derivatives (BOPs) as potential dual inhibitors of acetylcholinesterase and butyrylcholinesterase
por: Zarei, Samaneh, et al.
Publicado: (2021)

Design, Synthesis and Anticonvulsant Activity of 2-(2-Phenoxy) phenyl- 1,3,4-oxadiazole Derivatives
por: Tabatabai, Sayyed Abbas, et al.
Publicado: (2013)

3-[(4-Phenoxyphenyl)sulfanyl]-5-phenyl-1H-1,2,4-triazole
por: Ben Othman, Raja, et al.
Publicado: (2014)

Synthesis and Anticonvulsant Activity Evaluation of 3-alkoxy-4-(4-(hexyloxy/heptyloxy)phenyl)-4H-1,2,4 -triazole
por: Fang, Ying-Quan, et al.
Publicado: (2015)

3-(2-Chlorophenyl)-4-(4-nitrophenyl)-1H-1,2,4-triazole-5(4H)-thione
por: Nikoo, Abbas, et al.
Publicado: (2011)

Anti-Tubercular Properties of 4-Amino-5-(4-Fluoro-3- Phenoxyphenyl)-4H-1,2,4-Triazole-3-Thiol and Its Schiff Bases: Computational Input and Molecular Dynamics
por: Venugopala, Katharigatta N., et al.
Publicado: (2020)

Synthesis, analgesic and anti-inflammatory activities of new methyl-imidazolyl-1,3,4-oxadiazoles and 1,2,4-triazoles
por: Almasirad, Ali, et al.
Publicado: (2014)

An efficient piecewise linear model for predicting activity of caspase-3 inhibitors
por: Firoozpour, Loghman, et al.
Publicado: (2012)

Synthesis and cytotoxic evaluation of some new[1,3]dioxolo[4,5-g]chromen-8-one derivatives
por: Alipour, Eskandar, et al.
Publicado: (2014)

Anticonvulsant Effectiveness and Neurotoxicity Profile of 4-butyl-5-[(4-chloro-2-methylphenoxy)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione (TPL-16) in Mice
por: Drabik, Magdalena, et al.
Publicado: (2020)

4-Aryl-4H-naphthopyrans derivatives: one-pot synthesis, evaluation of Src kinase inhibitory and anti-proliferative activities
por: Rafinejad, Ali, et al.
Publicado: (2012)

Hybridization of the effective pharmacophores for treatment of epilepsy: design, synthesis, in vivo anticonvulsant activity, and in silico studies of phenoxyphenyl-1,3,4-oxadiazole-thio-N-phenylacetamid hybrids
por: Fakhrioliaei, Azadeh, et al.
Publicado: (2023)

Synthesis, α-Glucosidase inhibitory activity and docking studies of Novel Ethyl 1,2,3-triazol-4-ylmethylthio-5,6-diphenylpyridazine-4-carboxylate derivatives
por: Firoozpour, Loghman, et al.
Publicado: (2023)

1-(4-Chlorophenyl)-1H-1,2,4-triazol-5(4H)-one
por: Kattimani, Pramod P., et al.
Publicado: (2014)

Studies on the Anticonvulsant Activity and Influence on GABA-ergic Neurotransmission of 1,2,4-Triazole-3-thione-Based Compounds
por: Plech, Tomasz, et al.
Publicado: (2014)

5-Amino-3-(4H-1,2,4-triazol-4-yl)-1H-1,2,4-triazole
por: Liu, Bing, et al.
Publicado: (2012)

4-Amino-3-(4-chlorophenyl)-1H-1,2,4-triazole-5(4H)-thione
por: Natarajan, Sampath, et al.
Publicado: (2012)

N-Substituted indole carbohydrazide derivatives: synthesis and evaluation of their antiplatelet aggregation activity
por: Mirfazli, Seyedeh Sara, et al.
Publicado: (2014)

4-(4-Chlorophenyl)-5-(4-nitrophenyl)-3-phenyl-4H-1,2,4-triazole
por: Hu, Jing, et al.
Publicado: (2007)

1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy
por: Kaproń, Barbara, et al.
Publicado: (2020)

Effect of Linker Elongation on the VGSC Affinity and Anticonvulsant Activity among 4-Alkyl-5-aryl-1,2,4-triazole-3-thione Derivatives
por: Paruch, Kinga, et al.
Publicado: (2023)

Design, Synthesis, and In Vitro and In Vivo Evaluation of Novel Fluconazole-Based Compounds with Promising Antifungal Activities
por: Shafiei, Mohammad, et al.
Publicado: (2021)

4-(1,2,4-Triazol-1-yl)aniline
por: Fun, Hoong-Kun, et al.
Publicado: (2010)

Thermal Rearrangement of Allyl Substituted Unsymmetric 4H-1,2,4-Triazoles to the Corresponding 1H-1,2,4-triazoles.
por: Jørgensen, Kåre B., et al.
Publicado: (2001)

2-[(3-Aminoalkyl-(alkaryl-,aryl-))-(1)H-1,2,4-triazol-5-yl]anilines: synthesis and anticonvulsant activity
por: MARTYNENKO, Yulya, et al.
Publicado: (2020)

Novel N-2-(Furyl)-2-(chlorobenzyloxyimino) Ethyl Piperazinyl Quinolones: Synthesis, Cytotoxic Evaluation and Structure-Activity Relationship
por: Mohammadhosseini, Negar, et al.
Publicado: (2015)

4-[(E)-(4-Chlorobenzylidene)amino]-3-methyl-1H-1,2,4-triazole-5(4H)-thione
por: Sarojini, B. K., et al.
Publicado: (2013)

Synthesis of N-arylidene-2-(2-Phenoxyphenyl) Acetohydrazides as Anti-Inflammatory Agents
por: Shekarchi, Maral, et al.
Publicado: (2011)

Regioselectivity in the Thermal Rearrangement of Unsymmetrical 4-Methyl-4H-1,2,4-triazoles to 1-Methyl-1H-1,2,4-triazoles
por: Gautun, Odd R., et al.
Publicado: (2001)

[Hydrogen bis(1,2,4-triazole)] 1,2,4-triazolium bis(3-carboxy-4-hydroxybenzenesulfonate) 1,2,4-triazole disolvate
por: Qiu, Ming-qiang
Publicado: (2010)

7-Chloro-3-phenylbenzo[4,5]thiazolo[2,3-c][1,2,4]triazole
por: Fun, Hoong-Kun, et al.
Publicado: (2011)

3-Benzamidomethyl-4-[(E)-2-chlorobenzylideneamino]-1H-1,2,4-triazole-5(4H)-thione
por: Fun, Hoong-Kun, et al.
Publicado: (2008)

Synthesis and Evaluation of the Anticonvulsant Activities of 4-(2-(Alkylthio)benzo[d]oxazol-5-yl)-2,4-dihydro-3H-1,2,4-triazol-3-ones
por: Song, Ming-Xia, et al.
Publicado: (2018)

2-(4H-1,2,4-Triazol-4-yl)pyrimidine
por: Wang, Qian, et al.
Publicado: (2011)

2-(4H-1,2,4-Triazol-4-yl)phenol
por: Zhao, Wang, et al.
Publicado: (2010)

5-(4-Phenoxyphenyl)-1,3,4-thiadiazol-2-amine
por: Wan, Rong, et al.
Publicado: (2009)

Synthesis and Anticonvulsant Evaluation of some New 6-(Substituted-phenyl)thiazolo[3,2-b][1,2,4]triazole Derivatives in Mice
por: Deng, Xian-Qing, et al.
Publicado: (2014)

Synthesis, Anticonvulsant, Antimicrobial and Analgesic activity of Novel 1,2,4-Dithiazoles
por: Gupta, A., et al.
Publicado: (2008)

An insight on medicinal attributes of 1,2,4-triazoles
por: Aggarwal, Ranjana, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9amrfp13bakg680irf6di08e3o