Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors

A class of tripeptidyl transition state inhibitors containing a P1 glutamine surrogate, a P2 leucine, and a P3 arylalanines, was found to potently inhibit Norwalk virus replication in enzyme and cell based assays. An array of warheads, including aldehyde, α-ketoamide, bisulfite adduct, and α-hydroxy...

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Detalles Bibliográficos
Autores principales: Prior, Allan M., Kim, Yunjeong, Weerasekara, Sahani, Moroze, Meghan, Alliston, Kevin R., Uy, Roxanne Adeline Z., Groutas, William C., Chang, Kyeong-Ok, Hua, Duy H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863581/
https://www.ncbi.nlm.nih.gov/pubmed/24125888
http://dx.doi.org/10.1016/j.bmcl.2013.09.070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863581/
https://www.ncbi.nlm.nih.gov/pubmed/24125888
http://dx.doi.org/10.1016/j.bmcl.2013.09.070

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