Mechanosensing of DNA bending in a single specific protein-DNA complex

Many crucial biological processes are regulated by mechanical stimuli. Here, we report new findings that pico-Newton forces can drastically affect the stability of the site-specific DNA binding of a single transcription factor, the E. coli integration host factor (IHF), by stretching a short ~150 nm...

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Detalles Bibliográficos
Autores principales: Le, Shimin, Chen, Hu, Cong, Peiwen, Lin, Jie, Dröge, Peter, Yan, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863814/
https://www.ncbi.nlm.nih.gov/pubmed/24336435
http://dx.doi.org/10.1038/srep03508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863814/
https://www.ncbi.nlm.nih.gov/pubmed/24336435
http://dx.doi.org/10.1038/srep03508

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