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Dual-Targeting Pro-apoptotic Peptide for Programmed Cancer Cell Death via Specific Mitochondria Damage

Mitochondria are vital organelles to eukaryotic cells. Damage to mitochondria will cause irreversible cell death or apoptosis. In this report, we aim at programmed cancer cell death via specific mitochondrial damage. Herein, a functionalized pro-apoptotic peptide demonstrates a dual-targeting capabi...

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Autores principales: Chen, Wei-Hai, Xu, Xiao-Ding, Luo, Guo-Feng, Jia, Hui-Zhen, Lei, Qi, Cheng, Si-Xue, Zhuo, Ren-Xi, Zhang, Xian-Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863817/
https://www.ncbi.nlm.nih.gov/pubmed/24336626
http://dx.doi.org/10.1038/srep03468
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author Chen, Wei-Hai
Xu, Xiao-Ding
Luo, Guo-Feng
Jia, Hui-Zhen
Lei, Qi
Cheng, Si-Xue
Zhuo, Ren-Xi
Zhang, Xian-Zheng
author_facet Chen, Wei-Hai
Xu, Xiao-Ding
Luo, Guo-Feng
Jia, Hui-Zhen
Lei, Qi
Cheng, Si-Xue
Zhuo, Ren-Xi
Zhang, Xian-Zheng
author_sort Chen, Wei-Hai
collection PubMed
description Mitochondria are vital organelles to eukaryotic cells. Damage to mitochondria will cause irreversible cell death or apoptosis. In this report, we aim at programmed cancer cell death via specific mitochondrial damage. Herein, a functionalized pro-apoptotic peptide demonstrates a dual-targeting capability using folic acid (FA) (targeting agent I) and triphenylphosphonium (TPP) cation (targeting agent II). FA is a cancer-targeting agent, which can increase the cellular uptake of the pro-apoptotic peptide via receptor-mediated endocytosis. And the TPP cation is the mitochondrial targeting agent, which specifically delivers the pro-apoptotic peptide to its particular subcellular mitochondria after internalized by cancer cells. Then the pro-apoptotic peptide accumulates in mitochondria and causes its serious damage. This dual-targeting strategy has the potential to effectively transport the pro-apoptotic peptide to targeted cancer cell mitochondria, inducing mitochondrial dysfunction and triggering the mitochondria-dependent apoptosis to efficiently eliminate cancer cells.
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spelling pubmed-38638172013-12-20 Dual-Targeting Pro-apoptotic Peptide for Programmed Cancer Cell Death via Specific Mitochondria Damage Chen, Wei-Hai Xu, Xiao-Ding Luo, Guo-Feng Jia, Hui-Zhen Lei, Qi Cheng, Si-Xue Zhuo, Ren-Xi Zhang, Xian-Zheng Sci Rep Article Mitochondria are vital organelles to eukaryotic cells. Damage to mitochondria will cause irreversible cell death or apoptosis. In this report, we aim at programmed cancer cell death via specific mitochondrial damage. Herein, a functionalized pro-apoptotic peptide demonstrates a dual-targeting capability using folic acid (FA) (targeting agent I) and triphenylphosphonium (TPP) cation (targeting agent II). FA is a cancer-targeting agent, which can increase the cellular uptake of the pro-apoptotic peptide via receptor-mediated endocytosis. And the TPP cation is the mitochondrial targeting agent, which specifically delivers the pro-apoptotic peptide to its particular subcellular mitochondria after internalized by cancer cells. Then the pro-apoptotic peptide accumulates in mitochondria and causes its serious damage. This dual-targeting strategy has the potential to effectively transport the pro-apoptotic peptide to targeted cancer cell mitochondria, inducing mitochondrial dysfunction and triggering the mitochondria-dependent apoptosis to efficiently eliminate cancer cells. Nature Publishing Group 2013-12-16 /pmc/articles/PMC3863817/ /pubmed/24336626 http://dx.doi.org/10.1038/srep03468 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Article
Chen, Wei-Hai
Xu, Xiao-Ding
Luo, Guo-Feng
Jia, Hui-Zhen
Lei, Qi
Cheng, Si-Xue
Zhuo, Ren-Xi
Zhang, Xian-Zheng
Dual-Targeting Pro-apoptotic Peptide for Programmed Cancer Cell Death via Specific Mitochondria Damage
title Dual-Targeting Pro-apoptotic Peptide for Programmed Cancer Cell Death via Specific Mitochondria Damage
title_full Dual-Targeting Pro-apoptotic Peptide for Programmed Cancer Cell Death via Specific Mitochondria Damage
title_fullStr Dual-Targeting Pro-apoptotic Peptide for Programmed Cancer Cell Death via Specific Mitochondria Damage
title_full_unstemmed Dual-Targeting Pro-apoptotic Peptide for Programmed Cancer Cell Death via Specific Mitochondria Damage
title_short Dual-Targeting Pro-apoptotic Peptide for Programmed Cancer Cell Death via Specific Mitochondria Damage
title_sort dual-targeting pro-apoptotic peptide for programmed cancer cell death via specific mitochondria damage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863817/
https://www.ncbi.nlm.nih.gov/pubmed/24336626
http://dx.doi.org/10.1038/srep03468
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