Influenza A(H7N9) virus gains neuraminidase inhibitor resistance without loss of in vivo virulence or transmissibility

Without baseline human immunity to the emergent avian influenza A(H7N9) virus, neuraminidase inhibitors are vital for controlling viral replication in severe infections. An amino acid change in the viral neuraminidase associated with drug resistance, NA-R292K (N2 numbering), has been found in some H...

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Detalles Bibliográficos
Autores principales: Hai, Rong, Schmolke, Mirco, Leyva-Grado, Victor H., Thangavel, Rajagowthamee R., Margine, Irina, Jaffe, Eric L., Krammer, Florian, Solórzano, Alicia, García-Sastre, Adolfo, Palese, Peter, Bouvier, Nicole M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863970/
https://www.ncbi.nlm.nih.gov/pubmed/24326875
http://dx.doi.org/10.1038/ncomms3854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863970/
https://www.ncbi.nlm.nih.gov/pubmed/24326875
http://dx.doi.org/10.1038/ncomms3854

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