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Influenza A(H7N9) virus gains neuraminidase inhibitor resistance without loss of in vivo virulence or transmissibility
Without baseline human immunity to the emergent avian influenza A(H7N9) virus, neuraminidase inhibitors are vital for controlling viral replication in severe infections. An amino acid change in the viral neuraminidase associated with drug resistance, NA-R292K (N2 numbering), has been found in some H...
Autores principales: | Hai, Rong, Schmolke, Mirco, Leyva-Grado, Victor H., Thangavel, Rajagowthamee R., Margine, Irina, Jaffe, Eric L., Krammer, Florian, Solórzano, Alicia, García-Sastre, Adolfo, Palese, Peter, Bouvier, Nicole M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863970/ https://www.ncbi.nlm.nih.gov/pubmed/24326875 http://dx.doi.org/10.1038/ncomms3854 |
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