Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain

Clostridium difficile infection is the main cause of healthcare-acquired diarrhea in the developed world. In addition to the main virulence factors toxin A and B, epidemic, PCR Ribotype 027 strains, such as R20291, produce a third toxin, CDT. To develop effective medical countermeasures, it is impor...

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Detalles Bibliográficos
Autores principales: Kuehne, Sarah A., Collery, Mark M., Kelly, Michelle L., Cartman, Stephen T., Cockayne, Alan, Minton, Nigel P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864386/
https://www.ncbi.nlm.nih.gov/pubmed/23935202
http://dx.doi.org/10.1093/infdis/jit426
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author Kuehne, Sarah A.
Collery, Mark M.
Kelly, Michelle L.
Cartman, Stephen T.
Cockayne, Alan
Minton, Nigel P.
author_facet Kuehne, Sarah A.
Collery, Mark M.
Kelly, Michelle L.
Cartman, Stephen T.
Cockayne, Alan
Minton, Nigel P.
author_sort Kuehne, Sarah A.
collection PubMed
description Clostridium difficile infection is the main cause of healthcare-acquired diarrhea in the developed world. In addition to the main virulence factors toxin A and B, epidemic, PCR Ribotype 027 strains, such as R20291, produce a third toxin, CDT. To develop effective medical countermeasures, it is important to understand the importance of each toxin. Accordingly, we created all possible combinations of isogenic toxin mutants of R20291 and assessed their virulence. We demonstrated that either toxin A or toxin B alone can cause fulminant disease in the hamster infection model and present tantalizing data that C. difficile toxin may also contribute to virulence.
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spelling pubmed-38643862013-12-17 Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain Kuehne, Sarah A. Collery, Mark M. Kelly, Michelle L. Cartman, Stephen T. Cockayne, Alan Minton, Nigel P. J Infect Dis Major Articles and Brief Reports Clostridium difficile infection is the main cause of healthcare-acquired diarrhea in the developed world. In addition to the main virulence factors toxin A and B, epidemic, PCR Ribotype 027 strains, such as R20291, produce a third toxin, CDT. To develop effective medical countermeasures, it is important to understand the importance of each toxin. Accordingly, we created all possible combinations of isogenic toxin mutants of R20291 and assessed their virulence. We demonstrated that either toxin A or toxin B alone can cause fulminant disease in the hamster infection model and present tantalizing data that C. difficile toxin may also contribute to virulence. Oxford University Press 2014-01-01 2013-08-08 /pmc/articles/PMC3864386/ /pubmed/23935202 http://dx.doi.org/10.1093/infdis/jit426 Text en © The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Major Articles and Brief Reports
Kuehne, Sarah A.
Collery, Mark M.
Kelly, Michelle L.
Cartman, Stephen T.
Cockayne, Alan
Minton, Nigel P.
Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain
title Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain
title_full Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain
title_fullStr Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain
title_full_unstemmed Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain
title_short Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain
title_sort importance of toxin a, toxin b, and cdt in virulence of an epidemic clostridium difficile strain
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864386/
https://www.ncbi.nlm.nih.gov/pubmed/23935202
http://dx.doi.org/10.1093/infdis/jit426
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