HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation

The hepatitis C virus (HCV) internal ribosome entry site (IRES) drives non-canonical initiation of protein synthesis necessary for viral replication. HCV IRES functional studies have focused on 80S ribosome formation, but have not explored roles after the 80S ribosome is poised at the start codon. H...

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Detalles Bibliográficos
Autores principales: Filbin, Megan E., Vollmar, Breanna S., Shi, Dan, Gonen, Tamir, Kieft, Jeffrey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864654/
https://www.ncbi.nlm.nih.gov/pubmed/23262488
http://dx.doi.org/10.1038/nsmb.2465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864654/
https://www.ncbi.nlm.nih.gov/pubmed/23262488
http://dx.doi.org/10.1038/nsmb.2465

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