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HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation
The hepatitis C virus (HCV) internal ribosome entry site (IRES) drives non-canonical initiation of protein synthesis necessary for viral replication. HCV IRES functional studies have focused on 80S ribosome formation, but have not explored roles after the 80S ribosome is poised at the start codon. H...
Autores principales: | Filbin, Megan E., Vollmar, Breanna S., Shi, Dan, Gonen, Tamir, Kieft, Jeffrey S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864654/ https://www.ncbi.nlm.nih.gov/pubmed/23262488 http://dx.doi.org/10.1038/nsmb.2465 |
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