Ras and Rac1, Frequently Mutated in Melanomas, Are Activated by Superoxide Anion, Modulate Dnmt1 Level and Are Causally Related to Melanocyte Malignant Transformation

A melanocyte malignant transformation model was developed in our laboratory, in which different melanoma cell lines were obtained after submitting the non-tumorigenic melanocyte lineage melan-a to sequential cycles of anchorage impediment. Our group has already showed that increased superoxide level...

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Detalles Bibliográficos
Autores principales: Molognoni, Fernanda, de Melo, Fabiana Henriques Machado, da Silva, Camila Tainah, Jasiulionis, Miriam Galvonas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864863/
https://www.ncbi.nlm.nih.gov/pubmed/24358134
http://dx.doi.org/10.1371/journal.pone.0081937

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864863/
https://www.ncbi.nlm.nih.gov/pubmed/24358134
http://dx.doi.org/10.1371/journal.pone.0081937

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