MicroRNA-Regulated Non-Viral Vectors with Improved Tumor Specificity in an Orthotopic Rat Model of Hepatocellular Carcinoma

In hepatocellular carcinoma, tumor specificity of gene therapy is of utmost importance to preserve liver function. MicroRNAs are powerful negative regulators of gene expression and many are down-regulated in human HCC. We identified seven miRNAs that are also down-regulated in tumors in a rat hepato...

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Detalles Bibliográficos
Autores principales: Ronald, John A., Katzenberg, Regina, Nielsen, Carsten H., Jae, Hwan Jun, Hofmann, Lawrence V., Gambhir, Sanjiv S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864878/
https://www.ncbi.nlm.nih.gov/pubmed/23719066
http://dx.doi.org/10.1038/gt.2013.24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864878/
https://www.ncbi.nlm.nih.gov/pubmed/23719066
http://dx.doi.org/10.1038/gt.2013.24

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