Soluble β-amyloid Precursor Protein Alpha Binds to p75 Neurotrophin Receptor to Promote Neurite Outgrowth

BACKGROUND: The cleavage of β-amyloid precursor protein (APP) generates multiple proteins: Soluble β-amyloid Precursor Protein Alpha (sAPPα), sAPPβ, and amyloid β (Aβ). Previous studies have shown that sAPPα and sAPPβ possess neurotrophic properties, whereas Aβ is neurotoxic. However, the underlying...

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Detalles Bibliográficos
Autores principales: Hasebe, Noriko, Fujita, Yuki, Ueno, Masaki, Yoshimura, Kazuhiro, Fujino, Yuji, Yamashita, Toshihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864954/
https://www.ncbi.nlm.nih.gov/pubmed/24358169
http://dx.doi.org/10.1371/journal.pone.0082321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864954/
https://www.ncbi.nlm.nih.gov/pubmed/24358169
http://dx.doi.org/10.1371/journal.pone.0082321

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