Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo

The generation of hematopoietic stem cells (HSCs) from hemogenic endothelium within the aorta, gonad, mesonephros (AGM) region of the mammalian embryo is crucial for development of the adult hematopoietic system. We described a deletion of a Gata2 cis-element (+9.5) that depletes fetal liver HSCs, i...

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Detalles Bibliográficos
Autores principales: Gao, Xin, Johnson, Kirby D., Chang, Yuan-I, Boyer, Meghan E., Dewey, Colin N., Zhang, Jing, Bresnick, Emery H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865483/
https://www.ncbi.nlm.nih.gov/pubmed/24297994
http://dx.doi.org/10.1084/jem.20130733

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865483/
https://www.ncbi.nlm.nih.gov/pubmed/24297994
http://dx.doi.org/10.1084/jem.20130733

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