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Inhibition of the activity of poly (ADP-ribose) polymerase reduces heart ischaemia/reperfusion injury via suppressing JNK-mediated AIF translocation

Poly (ADP-ribose) polymerase (PARP) has been proposed to play an important role in the pathogenesis of heart ischaemia/reperfusion (I/R) injury. However, the mechanisms of PARP-mediated heart I/R injury in vivo are still not thoroughly understood. Therefore, in this study, we investigate the effect...

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Detalles Bibliográficos
Autores principales: Song, Zhao-Feng, Ji, Xiao-Ping, Li, Xiao-Xing, Wang, Sheng-Jun, Wang, Shu-Hua, Yun-Zhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865666/
https://www.ncbi.nlm.nih.gov/pubmed/18782186
http://dx.doi.org/10.1111/j.1582-4934.2008.00183.x