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Transgenic expression of the human LEDGF/p75 gene relieves the species barrier against HIV-1 infection in mouse cells
Attempts to create mouse models for AIDS have been hampered by species barriers in HIV-1 infection. We previously showed that the nuclear accumulation of HIV-1 preintegration complex (PIC) was suppressed in mouse cells. Lens epithelium-derived growth factor (LEDGF/p75) is a host factor identified as...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865800/ https://www.ncbi.nlm.nih.gov/pubmed/24381568 http://dx.doi.org/10.3389/fmicb.2013.00377 |