Valproic Acid Causes Proteasomal Degradation of DICER and Influences miRNA Expression

Valproic acid (VPA) is a commonly used drug to treat epilepsy and bipolar disorders. Known properties of VPA are inhibitions of histone deacetylases and activation of extracellular signal regulated kinases (ERK), which cannot fully explain VPA’s clinical features. We found that VPA induces the prote...

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Detalles Bibliográficos
Autores principales: Zhang, Zhaiyi, Convertini, Paolo, Shen, Manli, Xu, Xiu, Lemoine, Frédéric, de la Grange, Pierre, Andres, Douglas A., Stamm, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866160/
https://www.ncbi.nlm.nih.gov/pubmed/24358235
http://dx.doi.org/10.1371/journal.pone.0082895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866160/
https://www.ncbi.nlm.nih.gov/pubmed/24358235
http://dx.doi.org/10.1371/journal.pone.0082895

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