Cargando…

Id4 dependent acetylation restores mutant-p53 transcriptional activity

BACKGROUND: The mechanisms that can restore biological activity of mutant p53 are an area of high interest given that mutant p53 expression is observed in one third of prostate cancer. Here we demonstrate that Id4, an HLH transcriptional regulator and a tumor suppressor, can restore the mutant p53 t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Knowell, Ashley E, Patel, Divya, Morton, Derrick J, Sharma, Pankaj, Glymph, Shanora, Chaudhary, Jaideep
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866570/ https://www.ncbi.nlm.nih.gov/pubmed/24330748 http://dx.doi.org/10.1186/1476-4598-12-161

Ejemplares similares

ID4 regulates transcriptional activity of wild type and mutant p53 via K373 acetylation
por: Morton, Derrick J, et al.
Publicado: (2016)

Id1 and Id3 expression is associated with increasing grade of prostate cancer: Id3 preferentially regulates CDKN1B
por: Sharma, Pankaj, et al.
Publicado: (2012)

Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN
por: Sharma, Pankaj, et al.
Publicado: (2013)

Intra-tumoral delivery of functional ID4 protein via PCL/maltodextrin nano-particle inhibits prostate cancer growth
por: Korang-Yeboah, Maxwell, et al.
Publicado: (2016)

Epigenetic inactivation of inhibitor of differentiation 4 (Id4) correlates with prostate cancer
por: Sharma, Pankaj, et al.
Publicado: (2012)

EZH2 dependent H3K27me3 is involved in epigenetic silencing of ID4 in prostate cancer
por: Chinaranagari, Swathi, et al.
Publicado: (2014)

Inactivation of ID4 promotes a CRPC phenotype with constitutive AR activation through FKBP52
por: Joshi, Jugal Bharat, et al.
Publicado: (2017)

Inhibitor of differentiation 1 (Id1) promotes cell survival and proliferation of prostate epithelial cells
por: Schmidt, Michelle, et al.
Publicado: (2010)

Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation
por: Kong, Li Ren, et al.
Publicado: (2020)

The helix-loop-helix transcriptional regulator Id4 is required for terminal differentiation of luminal epithelial cells in the prostate
por: Hewa Bostanthirige, Dhanushka, et al.
Publicado: (2021)

SAT-481 TSH Adenoma: An Elusive Diagnosis
por: Chaudhary, Hira, et al.
Publicado: (2019)

A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C
por: Bauer, Matthias R, et al.
Publicado: (2019)

Inhibitor of differentiation 4 (Id4) is a potential tumor suppressor in prostate cancer
por: Carey, Jason PW, et al.
Publicado: (2009)

Glycerol restores p53-dependent radiosensitivity of human head and neck cancer cells bearing mutant p53
por: Ohnishi, K, et al.
Publicado: (2000)

Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53
por: Ohnishi, Takeo, et al.
Publicado: (2002)

Ligand dependent restoration of human TLR3 signaling and death in p53 mutant cells
por: Menendez, Daniel, et al.
Publicado: (2016)

Deciphering the acetylation code of p53 in transcription regulation and tumor suppression
por: Xia, Zhangchuan, et al.
Publicado: (2022)

Functional interplay between p53 acetylation and H1.2 phosphorylation in p53-regulated transcription
por: Kim, Kyunghwan, et al.
Publicado: (2012)

p53 Acetylation: Regulation and Consequences
por: Reed, Sara M., et al.
Publicado: (2014)

Insights into Regulators of p53 Acetylation
por: Nagasaka, Mai, et al.
Publicado: (2022)

Loss of peptidase D binding restores the tumor suppressor functions of oncogenic p53 mutants
por: Yang, Lu, et al.
Publicado: (2021)

5-Methoxyisatin N(4)-Pyrrolidinyl Thiosemicarbazone (MeOIstPyrd) Restores Mutant p53 and Inhibits the Growth of Skin Cancer Cells, In Vitro
por: Shahi, Nerina, et al.
Publicado: (2023)

Acetylation halts missense mutant p53 aggregation and rescues tumor suppression in non-small cell lung cancers
por: Xu, Daxing, et al.
Publicado: (2023)

Comparative computational and experimental analyses of some natural small molecules to restore transcriptional activation function of p53 in cancer cells harbouring wild type and p53(Ser46) mutant
por: Shefrin, Seyad, et al.
Publicado: (2022)

C-Terminal p53 Palindromic Tetrapeptide Restores Full Apoptotic Function to Mutant p53 Cancer Cells In Vitro and In Vivo
por: Fine, Robert L., et al.
Publicado: (2023)

Id1 Represses Osteoclast-Dependent Transcription and Affects Bone Formation and Hematopoiesis
por: Chan, April S., et al.
Publicado: (2009)

Suberoylanilide hydroxamic acid enhances the radiosensitivity of lung cancer cells through acetylated wild-type and mutant p53-dependent modulation of mitochondrial apoptosis
por: Wu, Kan, et al.
Publicado: (2021)

Transcriptional regulation of metastatic [Id]entity by KLF17
por: Iwanicki, Marcin P, et al.
Publicado: (2009)

Multiomic chromatin and transcription profiling with EpiDamID
por: Gopalan, Sneha, et al.
Publicado: (2022)

DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation
por: Tiane, Assia, et al.
Publicado: (2021)

SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma
por: Gomes, Sara, et al.
Publicado: (2019)

Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer
por: Sonego, Maura, et al.
Publicado: (2014)

Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer
por: Sonego, Maura, et al.
Publicado: (2013)

Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres
por: Ji, Qing, et al.
Publicado: (2008)

The biology of lysine acetylation integrates transcriptional programming and metabolism
por: Patel, Jigneshkumar, et al.
Publicado: (2011)

A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis
por: Yue, Xuetian, et al.
Publicado: (2016)

Gradual reduction in rRNA transcription triggers p53 acetylation and apoptosis via MYBBP1A
por: Kumazawa, Takuya, et al.
Publicado: (2015)

Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity
por: Loffreda, Alessia, et al.
Publicado: (2017)

α-Synuclein A53T Binds to Transcriptional Adapter 2-Alpha and Blocks Histone H3 Acetylation
por: Lee, Ji-Yeong, et al.
Publicado: (2021)

Predicting Transcriptional Activity of Multiple Site p53 Mutants Based on Hybrid Properties
por: Huang, Tao, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_n960jphdgj4jjmp6ve2g6luhl2