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Studies of translational misreading in vivo show that the ribosome very efficiently discriminates against most potential errors

Protein synthesis must rapidly and repeatedly discriminate between a single correct and many incorrect aminoacyl-tRNAs. We have attempted to measure the frequencies of all possible missense errors by tRNA[Image: see text], tRNA[Image: see text] and tRNA[Image: see text]. The most frequent errors inv...

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Detalles Bibliográficos
Autores principales: Manickam, Nandini, Nag, Nabanita, Abbasi, Aleeza, Patel, Kishan, Farabaugh, Philip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866648/
https://www.ncbi.nlm.nih.gov/pubmed/24249223
http://dx.doi.org/10.1261/rna.039792.113