Acetylation regulates Cyclophilin A catalysis, immunosuppression and HIV isomerization

Cyclophilin A (CypA) is a ubiquitous cis–trans prolyl isomerase with key roles in immunity and viral infection. CypA suppresses T-cell activation through cyclosporine complexation and is required for effective HIV-1 replication in host cells. We show that CypA is acetylated in diverse human cell lin...

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Detalles Bibliográficos
Autores principales: Lammers, Michael, Neumann, Heinz, Chin, Jason W, James, Leo C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867001/
https://www.ncbi.nlm.nih.gov/pubmed/20364129
http://dx.doi.org/10.1038/nchembio.342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867001/
https://www.ncbi.nlm.nih.gov/pubmed/20364129
http://dx.doi.org/10.1038/nchembio.342

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