Cargando…
Acetylation regulates Cyclophilin A catalysis, immunosuppression and HIV isomerization
Cyclophilin A (CypA) is a ubiquitous cis–trans prolyl isomerase with key roles in immunity and viral infection. CypA suppresses T-cell activation through cyclosporine complexation and is required for effective HIV-1 replication in host cells. We show that CypA is acetylated in diverse human cell lin...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2010
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867001/ https://www.ncbi.nlm.nih.gov/pubmed/20364129 http://dx.doi.org/10.1038/nchembio.342 |