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Biased Brownian ratcheting leads to pre-mRNA remodeling and capture prior to first-step splicing
The spliceosome is a dynamic ribonucleoprotein (RNP) machine that catalyzes the removal of introns in the two transesterification steps of eukaryotic pre-mRNA splicing. Here we used single molecule fluorescence resonance energy transfer to monitor the distance of the 5′ splice site (5′SS) and branch...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867266/ https://www.ncbi.nlm.nih.gov/pubmed/24240612 http://dx.doi.org/10.1038/nsmb.2704 |