S(+)-ibuprofen destabilizes MYC/MYCN and AKT, increases p53 expression, and induces unfolded protein response and favorable phenotype in neuroblastoma cell lines

Neuroblastoma is a common pediatric solid tumor that exhibits a striking clinical bipolarity favorable and unfavorable. The survival rate of children with unfavorable neuroblastoma remains low among all childhood cancers. MYCN and MYC play a crucial role in determining the malignancy of unfavorable...

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Detalles Bibliográficos
Autores principales: IKEGAKI, NAOHIKO, HICKS, SAKEENAH L., REGAN, PAUL L., JACOBS, JOSHUA, JUMBO, AMINA S., LEONHARDT, PAYTON, RAPPAPORT, ERIC F., TANG, XAO X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867363/
https://www.ncbi.nlm.nih.gov/pubmed/24173829
http://dx.doi.org/10.3892/ijo.2013.2148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867363/
https://www.ncbi.nlm.nih.gov/pubmed/24173829
http://dx.doi.org/10.3892/ijo.2013.2148

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