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Residues 240–250 in the C-Terminus of the Pirh2 Protein Complement the Function of the RING Domain in Self-Ubiquitination of the Pirh2 Protein

Pirh2 is a p53 inducible gene that encodes a RING-H2 domain and is proposed to be a main regulator of p53 protein, thus fine tuning the DNA damage response. Pirh2 interacts physically with p53 and promotes its MDM2-independent ubiquitination and subsequent degradation as well as participates in an a...

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Detalles Bibliográficos
Autores principales: Abou Zeinab, Rami, Wu, Hong, Sergi, Consolato, Leng, Roger P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867404/
https://www.ncbi.nlm.nih.gov/pubmed/24367557
http://dx.doi.org/10.1371/journal.pone.0082803