Prolyl-4-Hydroxylase 3 (PHD3) Expression Is Downregulated during Epithelial-to-Mesenchymal Transition

Prolyl-4-hydroxylation by the intracellular prolyl-4-hydroxylase enzymes (PHD1-3) serves as a master regulator of environmental oxygen sensing. The activity of these enzymes is tightly tied to tumorigenesis, as they regulate cell metabolism and angiogenesis through their control of hypoxia-inducible...

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Detalles Bibliográficos
Autores principales: Place, Trenton L., Nauseef, Jones T., Peterson, Maina K., Henry, Michael D., Mezhir, James J., Domann, Frederick E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867438/
https://www.ncbi.nlm.nih.gov/pubmed/24367580
http://dx.doi.org/10.1371/journal.pone.0083021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867438/
https://www.ncbi.nlm.nih.gov/pubmed/24367580
http://dx.doi.org/10.1371/journal.pone.0083021

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